Botox® vs. Xeomin®: Which One Is Right for You?

If you’re considering a wrinkle-relaxing treatment, you’ve probably come across two popular options: Botox® (onabotulinumtoxinA) and Xeomin® (incobotulinumtoxinA). Both are FDA-approved neuromodulators that temporarily soften expression lines by relaxing the tiny muscles that create them. But how do they differ, and which one is best for you?

At Prime Faith Aesthetics in Lewisville, TX, our goal is to deliver natural, balanced results with treatments tailored to your unique anatomy and goals. Below, we break down how Botox and Xeomin compare—so you can walk into your consultation informed and confident.

Quick refresher: how neuromodulators work

Neuromodulators are purified proteins derived from botulinum toxin type A. When injected in precise micro-doses, they block the release of acetylcholine, the chemical messenger that tells a muscle to contract. The result: the muscle rests, and dynamic lines (like frown lines, forehead lines, and crow’s feet) soften for several months. Dermatology authorities note typical cosmetic results last about 3–4 months for many patients (some longer, depending on dose, area, and individual metabolism).

If you’re new to injectables, start with our overview of neurotoxins and what to expect in-clinic: The Ultimate Guide to Neurotoxins.

Botox vs. Xeomin at a glance

• Active ingredient: Both use botulinum toxin type A.

• Formulation: Botox includes accessory (complexing) proteins; Xeomin is often called a “naked” toxin because it contains only the 150 kDa neurotoxin without accessory proteins.

• On-label cosmetic uses: Both are FDA-approved for glabellar lines (the “11s” between the brows); Botox Cosmetic also carries approvals for lateral canthal lines (crow’s feet) and forehead lines. (Clinicians often use either product off-label in other facial areas based on expertise.)

• Units are not interchangeable: Potency units differ by manufacturer assay—you cannot convert units 1:1 across brands.

• Duration: Most patients enjoy results for about 3–4 months; individual experiences vary by dose, area, and metabolism. American Academy of Dermatology

• Safety: Both have strong safety profiles when used by trained medical professionals with genuine product—more on safety below.

Digging deeper: what the formulation differences might mean

The most cited difference is formulation. Xeomin contains only the active neurotoxin (no accessory proteins). Some clinicians suggest this may reduce the risk of developing neutralizing antibodies over repeated treatments, which can blunt effectiveness. Evidence remains mixed, but this “naked” profile is the key point of distinction you’ll hear. Drugs.com summarizes the comparison succinctly, and FDA labeling emphasizes that dosing units and potencies shouldn’t be compared across brands.

Botox, the market pioneer, has the longest track record and the broadest range of FDA indications across cosmetic and therapeutic uses (including chronic migraine, hyperhidrosis, spasticity, and more). This extensive history provides a large body of real-world data on safety and technique.

Bottom line: Both are excellent tools. The “best” product is often the one your injector knows inside and out for your anatomy and goals.

How long do results last?

Most patients see peak softening at 7–14 days with improvement beginning as early as 3–7 days. Effects commonly last around 3–4 months, though some patients maintain results longer with consistent scheduling and appropriate dosing. Maintenance typically aligns with a 12-week retreatment interval noted in official labeling.

Where can they be used?

• Common cosmetic areas include:

• Glabellar lines (“11s”)

• Crow’s feet

• Forehead lines

• Bunny lines, lip flip, DAO (down-turned corners), chin dimpling, and masseter reduction (off-label, injector-dependent)

The American Academy of Dermatology and American Society of Plastic Surgeons both provide consumer-friendly overviews of appropriate uses and expectations.

Safety first: credentials and genuine product matter

When administered by trained medical professionals in proper settings, neuromodulators are considered safe with temporary, typically mild side effects (e.g., small injection-site bruises or tenderness). Rare but serious risks are outlined in FDA labeling for each brand.

Important: U.S. health authorities have warned about counterfeit botulinum toxin administered by unlicensed injectors, which led to hospitalizations. Always verify your provider and ensure authentic, FDA-approved product. Steer clear of “too-good-to-be-true” deals or non-medical settings.

At Prime Faith Aesthetics, treatments are performed by a Board-Certified Nurse Practitioner with medical oversight—your safety and natural-looking results come first. Learn more about our team and facility.

What about dosage and “units”?

A frequent question is: “How many units will I need?” It depends on your muscle strength, anatomy, and goals. Remember, a unit of Botox is not the same as a unit of Xeomin—they’re measured using different assays, so numbers don’t translate 1:1. Your injector will recommend a plan based on clinical assessment and your budget.

Will one look more ‘natural’ than the other?

Natural results come from technique, not just brand. Proper dosing and precise placement preserve expression while softening lines. Review our Injectables page to see how we plan treatments for balanced, face-wide harmony—and explore our anti-aging overview to understand how neuromodulators pair with skincare and collagen-stimulating treatments.

Cost considerations

Per-unit pricing varies by region and practice. While sticker prices can look similar, value depends on the total plan: recommended units, injector expertise, and follow-up care. At your consultation, we’ll build a transparent quote for your goals and timeline.

Who is a good candidate?

You’re likely a candidate if you’re healthy, not pregnant or nursing, and want to soften dynamic facial lines. During your visit, we’ll review your medical history, current medications (especially blood thinners), and prior experience with neuromodulators to ensure a safe, effective plan in line with FDA guidance and dermatology best practices.

Choosing between Botox and Xeomin: how we decide

During your Injectables consultation we’ll consider:

1. Treatment area & muscle pattern

   Some areas respond similarly to either brand; others may benefit from your injector’s preferred product based on spread and feel in that region.

2. Your history

   If you’ve used one brand consistently with great results, there’s often no reason to switch. If you’ve noticed diminished effect over time, we might trial the other product.

3. Timeline & events

   Need results by a specific date? We’ll plan your appointment so your peak softening lands right when you need it, based on typical 7–14 day peak onset and your prior response. FDA Access Data

4. Budget & maintenance

   We’ll map out a 3–4 month maintenance schedule (or customized intervals) that fits your lifestyle and skincare plan. American Academy of Dermatology

   
   

If you’re still unsure, we can treat one area with a conservative dose first, assess your response, then expand your plan—an approach many first-timers love.

FAQs

Is one “stronger” than the other?

Not exactly; they’re different formulations with non-interchangeable units. Effectiveness depends on dose, technique, and your physiology.

Does Xeomin work faster because it’s “naked”?

Onset for both usually falls within a few days, with full effect by two weeks. Individual variation matters more than formulation.

Can I switch brands later?

Yes. Many patients try both under professional guidance. If you ever feel results are waning, we may adjust dose, placement, or brand.

Are these treatments safe long-term?

When performed by qualified medical professionals using genuine product and appropriate dosing, neuromodulators have an excellent safety profile, supported by extensive FDA labeling and dermatology guidelines.

Why choose Prime Faith Aesthetics

• Treatments by a Board-Certified Nurse Practitioner with medical oversight

• A conservative, natural-results philosophy—you, refreshed

• A clean, professional environment with authentic FDA-approved product

• Education-first consultations and customized plans that may include skincare, microneedling, and fillers for comprehensive rejuvenation (explore our Services).

Want more background before you book? Read our primer: Botox in Lewisville, TX—The Secret to Smoother Skin

Ready to find your perfect fit?

Whether you choose Botox or Xeomin, a thoughtful plan and a skilled injector make all the difference. Let’s personalize a treatment strategy that aligns with your features, timeline, and budget.

👉 Book your consultation on our Injectables page, explore all Services, or contact us with questions. We serve Lewisville, Dallas, Plano, Grapevine, Coppell, and the surrounding DFW area.